Other Investigations

Should none of the above tests suggest a diagnosis of either PV or a secondary erythrocytosis then further more specialized tests may be undertaken. An oxygen dissociation curve can be performed to measure the P50 and identify patients with a high affinity hemoglobin. Any abnormality should prompt further investigations to identify the Hb, including Hb electrophoresis and direct sequencing. The Epo receptor gene may be assessed for truncating mutations (see pathogenesis) if this facility exists. The current limitation of using X-chromosome inactiva-tion patterns in elderly women has been discussed previously. However, it may have a place in supporting a diagnosis of PV in young women. Similarly platelet and megakaryocyte Tpo levels may have a place in the differentiation of PV from secondary erythrocytoses, but until methodologies are standardized this is also currently only a research tool.

10 Ways To Fight Off Cancer

10 Ways To Fight Off Cancer

Learning About 10 Ways Fight Off Cancer Can Have Amazing Benefits For Your Life The Best Tips On How To Keep This Killer At Bay Discovering that you or a loved one has cancer can be utterly terrifying. All the same, once you comprehend the causes of cancer and learn how to reverse those causes, you or your loved one may have more than a fighting chance of beating out cancer.

Get My Free Ebook

Post a comment