Miscellaneous Sites of Involvement

Skin lesions are rare in CML and when present, tend to be nodular.81 Multiple hemorrhagic soft tissue nodules have been reported in approximately 2 percent of patients with CML at presentation.82 Biopsy of these nodules has revealed extramedullary hematopoiesis associated with hemorrhage and necrosis. Meningeal involvement in the terminal blastic phase of CML is uncommon, but is even more atypical in chronic phase CML.82 Rapidly progressive pulmonary infiltrates due to granulocytic infiltration may occasionally occur.83

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