Info

a-IFN

dCF

2-CdA

Approved indication

Untreated HCL

IFN-refractory HCL

Both

Synthesis

Recombinant technology

Complex

Simple

Route of administration

Subcutaneous

Intravenous bolus

Intravenous infusion

Recommended dose

2 million U/m2, 3 times per week

4 mg/m2 every other week

0.1 mg/kg/day for 1 week

Duration of treatment

12 months

3 to 6 months

1 week

Major toxicities

Influenza-like syndrome

Nausea, early infections,

Culture-negative fever,

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