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Acute biphenotypic leukemias

phological definition must be complemented by immunophe-notyping and cytogenetics.

Recently, genetic features (cytogenetic and molecular genetic) as well as history of myelodysplasia and prior therapy have been shown to have a significant impact on the clinical behavior of acute leukemias. The major limitations of the FAB classification of the acute leukemias is the absence of cytogenet-ics and molecular genetic features, many of which were identified after the descriptions of the various FAB subtypes were described. The recently published WHO classification (11) combines the morphocytochemical features with pertinent chromosomal and molecular associations. These features are summarized in Tables 14-2 and 14-3. It is recommended that the reader turn to specific chapters in the extensive WHO publication for more in-depth information.

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