has not been reached for patients with VH gene mutations (p = .0 0 5)86 (Figure 6-5).

Within the subgroup of patients with unmutated VH genes, chromosome abnormalities retain prognostic significance. The median survival of germline cases is approximately 30 months for patients with del (17p13), 70 months for patients with del (11q23), and 90 months for patients with neither of these abnormalities. The prognostic significance of deletions of chromosomes 11q and 17q is also evident in germline cases with Binet stage A disease.85

These data, based on relatively small numbers of cases, demonstrate that the adverse prognostic significance of trisomy 12 is entirely due to its association with unmutated VH genes, whereas del (11q23) and del (17p13) appear to be independent prognostic factors.

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