HTLV Modulation of Redox Control

ATL-derived factor (ADF) was first described as an IL-2R-alpha chain-inducing factor.94 Further experiments determined that ADF was homologous to the bacterial reducing enzyme thiore-doxin.95 Thioredoxin acts as a proton donor to ribonucleotide reductase, a necessary enzyme in the process of DNA replication.96 Human thioredoxin/ADF is highly expressed in HTLV-1-infected cells.95,97

ADF has been shown to enhance the DNA binding of transcription factors AP-1 and NF-kB.98-101 The reduction of transcription factors allows them to form active DNA-binding

Identification of DNA damage

Binding to TRE

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