Figure 12—1. Phylogram showing the genetic relationship of the pol genes of the seven geni of exogenous retroviruses. The branch lengths are shown to scale and unique gene products are as indicated. MMTV, mouse mammary tumor virus; MPMV, Mason-Pfizer monkey virus; RSV, Rous sarcoma virus; Mo-MLV, Moloney murine leukemia virus; HFV, human foamy virus; SIVagm, simian immunodeficiency virus African green. The lentiviruses, PTLV/BLV, and spumaviruses are complex retroviruses because of the noted additional regulatory proteins encoded in their genomes. The other viruses are referred to as simple viruses because they lack such genes. Both the lentiviruses and the spumaviruses are cytopathic to the host cell, while all of the other geni transform the host cell.


Mo-MLV mammalian and reptilian type C

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