Erythropoietin Independent BFUE

As discussed in detail in the previous section on pathogenesis, clonogenic assays of purified progenitor cells from patients with PV have shown that their BFU-E are more sensitive than normal to a whole range of growth factors and may grow in serum containing medium without exogenous Epo. Unfortunately these culture techniques are laborious, poorly standardized, expensive, and not generally available outside the setting of research. The linked diagnostic criterion of low serum Epo can be more readily and cheaply demonstrated than the finding of erythropoietin-independent BFU-E.

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