Dysmegakaryopoiesis DysM

Qualitative changes are more common in DysM because the number of megakaryocytes is usually normal, although hypoplasia or hyperplasia can occasionally be seen. In the peripheral blood, large hypo- or hypergranular platelets can be found. In the bone marrow, morphological abnormalities of the megakaryocytic precursors can be seen in half of the patients. Commonly there are micromegakaryocytes (dwarf forms) (Plate 14-24), megakaryocytes with multiple small round, and separate nuclei, and large mononuclear forms.

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