Differentiated Acute Myeloid Leukemia Not Further Characterized

The immunophenotype of differentiated leukemic myeloblasts in principle corresponds to that of normal myeloblasts that express the immature markers CD34, CD117, and HLA-DR in addition to membrane CD33, CD13, and invariably CD65(s). At the same time, these leukemic cells show evidence of advanced myeloid maturation, such as positivity for CD64 and occasionally CD15, whereas CD11b (a marker of myelocytes and metamyelocytes as well as immature monocytes) and CD14 (a marker of mature monocytes) are absent. The level of maturation is an important prognostic indicator in AML.303,305

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