Curative Potential of Purine Nucleoside Analogues in Hairy Cell Leukemia

Hairy cells exhibit cytoplasmic reactivity against anti-CD22, CD25, CD103, DBA.44, and kappa or lambda monoclonals.114 Twenty-five to fifty percent of patients in morphologic complete remission after 2-CdA have minimal residual disease detected by immunohistochemical stains on marrow biop-sies.115,116 Wheaton et al. reported on bone marrow results in 39 HCL patients in apparent morphologic complete remission, 5 of whom (13 percent) had minimal residual disease based on immunohistochemistry.117 Forty percent with detectable minimal residual disease went on to relapse, compared with 7 percent of those without detectable disease. When evaluated by the polymerase chain reaction and clone-specific probes derived from the immunoglobulin heavy-chain genes, all seven patients in apparent complete remission following 2-CdA showed detectable minimal residual disease.118 Also, although in the

Table 8-6. Features of Alpha-Interferon (a-IFN), 2'-Deoxycoformycin (dCF), and 2-Chlorodeoxyadenosine (2-CdA) Treatment in

Hairy Cell Leukemia

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