Conclusion

CML is one of the most extensively studied human malignancies. It is the only neoplasm in which a single genetic event has been linked to the pathogenesis of the disease. CML is also a model for the multistep process of cancer progression in that clonal evolution accompanied by additional molecular hits precedes the clinical manifestations of CML transformation. The dissection of the signaling pathways and its molecular constituents has sparked a surge in the identification of new agents that act at specific sites in this network. Some of these drugs have already shown promising clinical activity. As this field will undoubtedly expand, new lessons are also learned to benefit patients with many other malignant and nonmalignant diseases. The paradigm of BCR-ABL is a powerful accolade to the contributions of basic science in cancer medicine.

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