Clonality Markers

The marrow karyotype is nearly always normal in ET. The 1 to 2 percent of ET patients who have variable karyotypic abnormalities might represent a subgroup with a poorer prognosis.8 The use of X chromosome-linked probes to establish clonality has limitations in female patients over 60 years, 25 to 30 percent of whom have apparent clonal granulocytes.9,10 In younger patients, only half can be shown to have clonal hemopoiesis, as discussed earlier, but this finding carries diagnostic significance.

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