Clinical Manifestations

About 25 percent of patients present with fatigue, 25 percent with repeated infections, and 25 percent with splenomegaly, which in a minority of patients may be massive, or with cytope-nias41 (Table 8-1). In 102 newly diagnosed HCL patients, 86 had anemia, 84 thrombocytopenia, and 78 neutropenia.42 Splenomegaly was present in 93 patients. Hepatomegaly is present in 20 percent of patients. Although peripheral adenopathy is rarely found clinically, less than 10 percent of patients have peripheral lymphadenopathy larger than 2 cm; now with the frequent use of computed tomographic (CT) scans in the initial evaluation, internal lymphadenopathy is increasingly recognized. Of 43 consecutive patients studied with CT scans, 6 (14 percent) had significant internal adenopathy; 3 had massive abdominal adenopathy (larger than 10 cm), and 1 had bulky adenopathy (5 to 10 cm).43 Hairy cell leukemia is typically associated with leukopenia, but up to 20 percent of patients may develop a leukemic phase,44 and 10 percent may present without discernible circulating hairy cells on light microscopy. Other laboratory findings may include liver function test

10 Ways To Fight Off Cancer

10 Ways To Fight Off Cancer

Learning About 10 Ways Fight Off Cancer Can Have Amazing Benefits For Your Life The Best Tips On How To Keep This Killer At Bay Discovering that you or a loved one has cancer can be utterly terrifying. All the same, once you comprehend the causes of cancer and learn how to reverse those causes, you or your loved one may have more than a fighting chance of beating out cancer.

Get My Free Ebook

Post a comment