CD56 Natural Killer Cell Acute Lymphocytic Leukemia

CD56-positive or NK cell ALL is a rare disease entity. In a recent ECOG database analysis, it accounted for 3 percent of adult ALL.250 In contrast with other reports reviewed in this paper,250 CD56+ ALL patients identified by ECOG expressed this NK-cell antigen on at least 90 percent of gated lymphoblasts, thus leaving no doubt regarding the suitability of this immunodiagnosis. The majority of CD56+ ALL cases present with a T-lineage immunophenotype, which is in line with the common developmental pathway of T lymphocytes and NK cells.271-273,275,278 However, the ECOG analysis unexpectedly revealed CD56 expression in two patients with unequivocal B-lineage ALL.250 Expression of B-lineage antigen in NK/T leukemia or lymphoma is an uncommon observation.355,356 A developmental link between NK and B cells has recently been established.253

10 Ways To Fight Off Cancer

10 Ways To Fight Off Cancer

Learning About 10 Ways Fight Off Cancer Can Have Amazing Benefits For Your Life The Best Tips On How To Keep This Killer At Bay Discovering that you or a loved one has cancer can be utterly terrifying. All the same, once you comprehend the causes of cancer and learn how to reverse those causes, you or your loved one may have more than a fighting chance of beating out cancer.

Get My Free Ebook


Post a comment