Brian JP Huntly Anthony Bench and Anthony R Green

Polycythaemia vera (PV) was first described in 1892 by

Vazquez,1 in a case report of a patient with ruddy cyanosis, splenomegaly, and an increased red cell count not associated with a congenital form of heart disease. A decade later in 1903 it was defined more clearly by Osler2 and the disease then became known as Vasquez-Osler disease until this eponymous term was superseded by PV. Along with essential thrombo-cythemia (ET) and idiopathic myelofibrosis (IMF) it is one of the chronic myeloproliferative disorders (MPDs)(see separate chapters), an overlapping spectrum of preleukemic disorders believed to result from acquired genetic changes in the hematopoietic stem cell compartment. These changes lead to perturbed stem cell function with overproduction of mature cells within one or more of the myeloid lineages and a variable predisposition to acute leukemia. The MPDs were first grouped together, along with chronic myelocytic leukemia (CML), by Dameshek in his seminal paper of 1951.3 CML is now considered to be a pathogenetically distinct entity, but shares several features with the other MPDs.

Your Heart and Nutrition

Your Heart and Nutrition

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