Analytic Epidemiology

No systematic or large studies have been undertaken on the possible etiological links in PP.

There are strong indications that a familial tendency exists,85 as does ethnic variation with lower rates in Japan86 and in U.S. Blacks87 than in European populations.

There are weak suggestions that previous malignancies, previous medical irradiation, and having been a frequent blood donor in the past may be risk factors.88

These observations should be treated with caution but there is some indication that risk factors might be similar to those of CML. This hypothesis, however, would require rigorous testing.

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