Anagrelide

Anagrelide is an oral imidazoquinazolin derivative that can be used to control the platelet count in patients with an MPD, including PV.121 Its mechanism of action is unclear but it appears to reduce the platelet count by suppressing the maturation of megakaryocytes and also suppresses the Hb levels by 1 to 2 g/L in a proportion of patients with ET. It has no effect on the peripheral leukocyte count. Reported side effects of anagre-lide relate to its inhibition of phosphodiesterase and consequent positive inotropic and vasodilator effects with transient headache, palpitations, and fluid retention being common.

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