Acute Myeloid Leukemia with t821q22q22

Acute myeloid leukemia with t(8;21)(q22;q22), resulting in AML1/ETO fusion gene transcription, is now recognized as a distinct disease entity based on its prognostic implications77,78 The classical immunophenotype of t(8;21) AML is rather unique, enabling diagnosis of this subtype even in the absence of cytogenetic-molecular information. These myeloblasts invariably express CD34 and commonly express CD19 and/or CD56.16'17'376'377 The combination of CD19 and CD34 is the most predictive one for t(8;21) AML;17 however, CD19 status does not appear to affect outcome in this AML subgroup.378 The increased frequency of extramedullary disease in t(8;21) AML may be related to the expression of CD56, the neural cell adhesion molecule.43,44 Expression of CD56 has been correlated with short remission duration and short survival in t(8;21) AML.24 Another adhesion molecule, the integrin CD11a, is characteristically absent from t(8;21) myeloblasts.18

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