A

78 (26-130)

Demonstrating median survival times in months with associated 95% confidence intervals: N = normal, A = abnormal. (Based on Reilly et al.28)

Demonstrating median survival times in months with associated 95% confidence intervals: N = normal, A = abnormal. (Based on Reilly et al.28)

for control of thrombocytosis, leukocytosis, and/or hypercata-bolic symptoms, and splenectomy or splenic irradiation for symptomatic splenomegaly. However, these conventional therapies have not been demonstrated to significantly influence the natural history of the disease, and as a result, asymptomatic individuals may not require intervention and should merely be observed at periodic intervals. In contrast, young patients with a poor prognosis should be identified and be considered for allogeneic bone marrow transplantation.

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