aAs of September 2001. Data from open studies were obtained from ref. 3; data from closed studies were obtained from the references given in the table.

Abbreviations: met, metastasis; HSV-TK, herpes simplex virus type 1 thymidine kinase gene; LacZ, E. coli p-galactosidase gene; 1716, HSV-1 with mutation in y34.5 gene; G207, HSV-1 mutated in y34.5 and large subunit of viral ribonucleotide reductase; it, intratumoral; sc, subcutaneous; id, intradermal; bm, reinfused back into bone marrow after ex vivo gene transfer; No. patients, number of patients enrolled in the trial; VPCs, vector producer cells; VPs, vector particles; retro, retrovirus; adeno, adenovirus; PFU, plaque-forming units; GCV (d), days during which 7 mg/kg twice a day intravenous ganciclovir was given, with day 0 being the day on which tumor resection and viral vector implantation were performed; surv, survival; prog, disease progression as defined by tumor growth or recurrence on MRI; GBM, glioblastoma multiforme; IFN, interferon; IGF, insulin-like growth factor; IL, interleukin; GM-CSF, granulocyte-macrophage colony-stimulating factor; met, metastasis.

Table 2B

Summary of Clinical Trials in Brain Tumor Gene Therapy: 11 Closed Trialsa

Table 2B

Summary of Clinical Trials in Brain Tumor Gene Therapy: 11 Closed Trialsa








No. of patients

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