Local delivery strategies have proved to be safe and effective in providing new treatment alternatives for various CNS lesions and diseases. Gliomas are the most established area of research with local delivery. These aggressive lesions have remained resistant to conventional treatment methods and require new treatment options. Local delivery strategies have evolved from local injection to polymer technology to CED, to meet these demands. As neurosurgeons move forward, they will need to address the growing need for new technology, and CED may offer the most promise. CED will allow versatility for incorporating new chemotherapeutic and immunotherapeutic agents into clinical studies, as it has already been validated as a safe treatment strategy in clinical trials. Ongoing and future clinical trials will further elucidate the safety and efficacy of CED and the other local delivery strategies with previously untested agents in the hope of improving the treatment of CNS diseases.

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