I

Fig. 3. M-FISH analysis of a metaphase obtained from the bone marrow of MDS patient. Note the complex karyotypic abnormalities with -3, -5,-11, and unexpected translocations t(5;17), and t(19;20) that could only be detected by the use of M-FISH. (Author's [SM] collaboration with Dr. Wei-Tong Hsu and Dr. Azra Raza at Rush University, Chicago, Illinois.) (Figure appears in color in insert following p. 172.)

Table 5

Comparison of the Overall Resolution of Different DNA Detection Techniques

Table 5

Comparison of the Overall Resolution of Different DNA Detection Techniques

Technique

Resolution

Metaphase chromosome banding

10 Mb

Metaphase FISH

1-10 Mb

M-FISH/SKY

~2-3 Mb

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