Hereditary Motor And Sensory Neuropathies

Estimated to affect 1 in 2500 individuals, Hereditary motor and sensory neuropathies (HMSNs), also termed Charcot-Marie-Tooth (CMT), are likely the most common inherited disorders of the peripheral nervous system. The classification and understanding of HMSN has evolved with each new technology, and as such, the number of distinct forms has expanded with time. Over 20 varieties with different identified loci or genes are now known (see Table 2). Virchow, Eichorst, and Charcot and Marie provided phenotypic accounts of the various forms of these peroneal muscular atrophies. It was on the basis of electrophysiologic, genetic, and histopathologic descriptions by Dyck and Lambert that the HMSN terminology arose (72). Patients frequently have high arches, hammertoes, and prominent plantar and dorsiflexor weaknesses. Progressive worsening of handicaps is the norm, but most patients do not lose the ability to walk and often require assistive devices. In contrast,

Table 2

Hereditary Motor and Sensory Neuropathy

Disease

Nerve Chromosomal conductions Inheritance location

Gene

Type 1

Table 2

Hereditary Motor and Sensory Neuropathy

Disease

Nerve Chromosomal conductions Inheritance location

Gene

Type 1

Peripheral Neuropathy Natural Treatment Options

Peripheral Neuropathy Natural Treatment Options

This guide will help millions of people understand this condition so that they can take control of their lives and make informed decisions. The ebook covers information on a vast number of different types of neuropathy. In addition, it will be a useful resource for their families, caregivers, and health care providers.

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