Bioinformatics can be used by pharmaceutical companies to advance therapeutics in developing drugs for specific targets such as proteases, kinases, nuclear hormone receptors, 7-transmembrane proteins, chemokines, cytokines, and adhesion molecules (32). Imatinib mesylate (Gleevec) is used successfully in the treatment of chronic myelogenous leukemia by interfering with an abnormal BCR-ABL tyrosine kinase protein (33). Gleevec was identified by using a high-throughput screen for tyrosine kinase inhibitors while optimizing its activity for specific kinases. Bioinformatics played a key role in the discovery of this drug through the ability to identify and target specific genetic markers. The success of this drug suggests that therapies based on genomic information will be effective.
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