The author gratefully acknowledges the suggestions and comments of Ruth A. Heim, Ph.D., and the generous contribution of figures from Sarah Adkins, Michelle L. Blalock, Kenneth J. Friedman, Ruth A. Heim, Ph.D., and William G. Learning (Molecular Genetics Laboratory, University of North Carolina Hospitals), Lori Terry and J. Carl Barrett, Ph.D. (Laboratory of Molecular Carcinogenesis, National Institute of Environmental Health Science), Marianna M. Goldrick, Ph.D.

(Ambion, Inc.), and Heui Ra Yoo (Molecular Diagnostics Laboratory, University of Maryland Medical Systems). The author thanks Kevin Halling, M.D., Ph.D. for his critical review of the manuscript.

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