Assisted ventilation ± sedation and muscle relaxation reduces respiratory muscle activity and thus the work of breathing. In cardiac failure or non-cardiogenic pulmonary oedema the resulting reduction in myocardial oxygen demand is more easily matched to the supply of oxygen.
Indications for ventilatory support
Ventilatory support (invasive or non-invasive) should be considered if:
Respiratory rate >30/min Vital capacity <10-15ml/min PaO2 < 11kPa on FIO2>0.4
PaCO2 high with significant respiratory acidosis (e.g. pH <7.2)
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