Systemic lupus erythematosis SLE

A non-organ specific autoimmune disease characterised by antinuclear antibodies with high titres of antidouble-stranded DNA antibodies. A vasculitis is prominent, although cutaneous and central nervous system involvement are not vasculitic. SLE may present to intensive care through pulmonary, renal or central nervous system involvement.

Renal failure

Renal failure is vasculitic in origin and may progress to end stage renal failure requiring long term dialysis. Early treatment with systemic steroids and immunosuppressives may halt disease progress.

Lupus pleurisy and pericarditis

Unlike rheumatoid pleurisy the pleural involvement in SLE is often painful and associated with large pleural effusions.

Pulmonary haemorrhage

Pulmonary haemorrhage is associated with renal failure and may be life threatening. Plasma exchange may be helpful.

Interstitial pneumonitis

Interstitial pneumonitis is uncommon in SLE. It is more likely that parenchymal infiltrates are infective in origin secondary to immunosuppressive therapy.

Pulmonary thromboembolic disease

Patients typically have a prolonged activated partial thromboplastin time due to circulating lupus anticoagulant. but are more prone to thrombotic episodes. Lupus anticoagulant is associated with anticardiolipin antibodies and a false positive VDRL. Recurrent pulmonary emboli may be associated with chronic pulmonary hypertension. Treatment is long term anticoagulation.


How To Deal With Rosacea and Eczema

How To Deal With Rosacea and Eczema

Rosacea and Eczema are two skin conditions that are fairly commonly found throughout the world. Each of them is characterized by different features, and can be both discomfiting as well as result in undesirable appearance features. In a nutshell, theyre problems that many would want to deal with.

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