Sucralfate Modes of action

• Sucralfate is a basic aluminium salt of sucrose octasulphate and is probably not absorbed from the gastrointestinal tract.

• Exerts a cytoprotective effect by preventing mucosal injury. A protective barrier is formed both over normal mucosa and any ulcer lesion providing protection against penetration of gastric acid, bile and pepsin as well as irritants such as aspirin and alcohol.

• Directly inhibits pepsin activity and absorbs bile salts.

• Weak antacid activity.

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