See also

Hypotension, p312; Tachyarrhythmias, p316; Bradyarrhythmias, p318; Acute coronary syndrome (1), p320; Acute coronary syndrome (2), p322; Heart failure — assessment, p324; Heart failure — management, p326; Diarrhoea, p340; Failure to open bowels, p342; Acute weakness, p368; Generalised seizures, p372; Hypercalcaemia, p426; Diabetic ketoacidosis, p442; Hypoadrenal crisis, p448; Systemic inflammation/multi-organ failure, p484; Hypothermia, p516; Pyrexia (1), p518; Pyrexia (2), p520


Hypoadrenal crisis Clinical features Primary hypoadrenalism

• Glucocorticoid deficiency (e.g. weakness, vomiting, diarrhoea

• Mineralocorticoid deficiency (e.g. dehydration, hyponatraemia hyperkalaemia)

Skin pigmentation due to ACTH excess

Secondary hypoadrenalism

• May be due to critical illness, steroid withdrawal after 2 weeks' treatment, hypopituitarism or etomidate use

• No skin pigmentation

• Features of mineralocorticoid deficiency may be absent

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