Relative potency and activity

Drug

Glucocorticoid activity

Mineralocorticoid activity

anti-

Equivalent inflammatory dose (mg)

Cortisone

+ +

+ +

25

Dexamethasone

+ + + +

0.75

Hydrocortisone

+ +

+ +

20

Methylprednisolone

+ + +

+

4

Prednisolone

+ + +

+

5

Prednisone

+ + +

+

5

Fludrocortisone

+

+ + + +

Drug dosages

Drug

Replacement dose

Anti-inflammatory dose

Dexamethasone

4-20mg tds IV

Hydrocortisone

20-30mg daily

100-200mg qds IV

Methylprednisolone

500mg-1g IV daily

Prednisolone

2.5-15mg mane

40-60mg od PO

Fludrocortisone

0.05-0.3mg daily

0 0

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