Relative persistence of colloid effect

Albumin

+ + +

Dextran 70

+ +

Succinylated gelatin

+ +

Polygeline

+

Hetastarch (high MW, high DS, low C2:C6 ratio)

++++

Hexastarch (medium MW, high DS, high C2:C6 ratio)

++++

Pentastarch (medium MW, low DS, low C2:C6 ratio)

+ +

Tetrastarch (low MW, low DS, high C2:C6 ratio)

+ +

• Persistence is dependent on molecular size and protection from metabolism.

• High DS and high C2:C6 ratio protect hydroxyethyl starch from metabolism.

• All artificial colloids are polydisperse (i.e. there is a range of molecular sizes).

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