Organisms and empiric starting antibiotic therapy

Organism

Patients often affected

Antibiotic and dosage regimen (alternatives in brackets)

Neisseria meningitidis (Meningococcus)

young adults

ceftriaxone 2-4 g IV od (cefotaxime 50 mg/kg IV 8-hrly) (benzylpenicillin 1.2 g IV 2-4-hrly) (chloramphenicol 12.5 mg/kg IV 6-hrly)

Streptococcus pneumoniae

(Pneumococcus)

older adults

ceftriaxone 2-4 g IV od (cefotaxime 50 mg/kg IV 8-hrly) (chloramphenicol 12.5 mg/kg IV 6-hrly)

Haemophilus influenzae

children

ceftriaxone 20-50 mg/kg IV od (cefotaxime 50 mg/kg IV 8-hrly) (chloramphenicol 12.5 mg/kg IV 6-hrly)

Listeria monocytogenes

elderly, immuno-compromised

ampicillin 1g IV 4-6-hrly plus gentamicin 120 mg IV stat, then 80 mg 8-12-hrly (adjust by plasma levels)

Mycobacterium tuberculosis

quadruple therapy (rifampicin/isoniazid/ ethambutol /pyrazinamide)

Cryptococcus neoformans

immuno-compromised

amphotericin B starting at 250 pg/kg IV od + flucytosine 50 mg/kg IV 6-hrly

Staph. aureus

flucloxacillin 2 g IV 6-hrly

0 0

Post a comment