Novel therapies in sepsis

Greater understanding of the pathophysiology of sepsis has stimulated the development and investigation of agents that modulate different components of the inflammatory response. These drugs have been targeted at triggers (e.g. endotoxin), cytokines (e.g. tumour necrosis factor, interleukin (IL)-1), and effector cells and their products (e.g. neutrophils, free oxygen radicals, nitric oxide) or aim to boost a general anti-inflammatory response (e.g. steroids). An increasing area of research is in replacement or augmentation of endogenous anti-inflammatory systems, e.g. activated Protein C, antithrombin-III, IL-10, as there is an increasing realisation of the degree of disruption and imbalance between pro- and anti-inflammatory substances.

Unfortunately, due to deficiencies in trial design and size, choice of appropriate patient, timing of drug administration, dosage, and lack of standardisation of concurrent therapies, only two agents ('low dose' hydrocortisone and activated Protein C) have been shown to produce outcome benefit in reasonably sized multicentre trials. For many other products, promising results from post-hoc subgroup analysis and from tightly controlled small patient studies have not been reproduced. Concern over cost has highlighted the potential budgetary implications of any successful therapy though, in terms of life years, the cost-benefit will be relatively cheap.

Cure Tennis Elbow Without Surgery

Cure Tennis Elbow Without Surgery

Everything you wanted to know about. How To Cure Tennis Elbow. Are you an athlete who suffers from tennis elbow? Contrary to popular opinion, most people who suffer from tennis elbow do not even play tennis. They get this condition, which is a torn tendon in the elbow, from the strain of using the same motions with the arm, repeatedly. If you have tennis elbow, you understand how the pain can disrupt your day.

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