Notes

Antimicrobials should be chosen according to microbial sensitivities, usually based on advice from the microbiology laboratory.

Appropriate empiric therapy for serious infections should be determined by likely organisms, taking into account known community and hospital infection and resistance patterns.

Up to 10% of penicillin-allergic patients are also cephalosporin-allergic.

Drug dosages (intravenous)

P.261

Benzylpenicillin 1.2g 6-hrly (2-hrly for pneumococcal pneumonia)

Flucloxacillin

500mg-2g 6-hrly

Ampicillin

500mg-1g 6-hrly

Piptazobactam 4.5g 6-8-hrly

Cefotaxime

1-4g 8-hrly

Ceftazidime

Ceftriaxone

Cefuroxime

Gentamicin

Amikacin

Tobramycin

Erythromycin

Metronidazole

Clindamycin

Ciprofloxacin

Co-trimoxazole

Imipenem

Meropenem

Rifampicin

Teicoplanin

Vancomycin

Linezolid

Chloramphenicol

Amphotericin

Flucytosine

Fluconazole

Caspofungin

Voriconazole

Itraconazole

2g 8-hrly

1-4g daily

750mg-1.5g 8-hrly

1.5mg/kg stat then by levels (usually 80mg 8-hrly)

7.5mg/kg stat then by levels (usually 500mg 12-hrly)

5mg/kg stat then by levels (usually 100mg 8-hrly)

500mg-1g 6-12-hrly

500mg 8-hrly or 1g 12-hrly PR

300-600mg 6-hrly

200-400mg 12-hrly

960mg 12-hrly in Pneumocystis carinii pneumonia

500mg-1g 8-hrly

600mg daily

400mg 12-hrly for 3 doses then 400mg daily

500mg 6-hrly (monitor levels)

600mg 12-hrly

1-2g 6-hrly

250jg-1mg/kg daily

25-50mg/kg 6-hrly

200-400mg daily

70mg stat then 50-70mg daily

400mg 12-hrly on first day then 200-300mg 12-hrly

200mg 12-hrly for 2 days then 200mg daily

0 0

Post a comment