Modes of action

bumetanide

. amiloride, spironolactone, potassium canrenoate

• Osmotic diuretics-

reduce distal tubular water reabsorption

• Thiazides — inhibit distal tubular Na + loss and carbonic anhydrase and increase Na + and K + exchange. This reduces the supply of H+ ions for exchange with Na+ ions producing and alkaline natriuresis with potassium loss

• Loop diuretics — inhibit Na+ and Cl- reabsorption in the ascending loop of Henle

• Potassium sparing diuretics — inhibit distal tubular Na+ and K+ exchange

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