Modes of action

• Heparin potentiates naturally occurring AT-III, reduces the adhesionof platelets to injured arterial walls, binds to platelets and promotes in vitro aggregation.

• LMW heparin appears to specifically influence factor Xa activity; its simpler pharmacokinetics allow for a smaller (two thirds) dose to be administered to the same effect.

• The effects of the prostanoids depend on the balance betweenTXA2 and PGI2.

• Sodium citrate chelates ionised calcium.

• Warfarin produces a controlled deficiency of vitamin K dependent coagulation factors (II, VII, IX and X).

• Activated Protein C is the activated form of the endogenous anticoagulant, Protein C

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