Measurement of COP

In a membrane oncometer the plasma sample is separated from a reference 0.9% saline solution by a membrane with a molecular weight exclusion between 10,000 and 30,000Da. The reference solution is in a closed chamber containing a pressure transducer. Saline will pass to the sample chamber by colloid osmosis creating a negative pressure in the reference chamber. When the negative pressure prevents any further flow across the membrane, it is equal to the COP of the sample. Normal plasma COP is 25-30mmHg.

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