Management is entirely supportive. If amniotic fluid embolism occurs prior to delivery urgent Caesarean section must be performed to prevent further embolisation.

Respiratory support

Oxygen (FIO2 0.6-1.0) must be provided. In many cases CPAP or mechanical ventilation will be required.

Cardiovascular support

Standard resuscitation principles apply with controlled fluid loading and inotropic support being started as required.

Haematological management

Management of the coagulopathy requires blood product therapy guided by laboratory assessment of coagulation times. In addition, some cases improve after treatment with cryoprecipitate, possible due to the effects of fibronectin replacement.


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