Inhaled nitric oxide

Nitric oxide is provided for inhalation from cylinders (1000ppm nitric oxide in nitrogen). It is diluted with inspiratory gases, either at the gas supply to the ventilator or in the inspiratory limb of the ventilator circuit, to provide an inhaled concentration of 1-40ppm, although most patients require less than 20ppm. Inhalation produces vasodilatation at the site of gas exchange, and may improve ventilation-perfusion matching and reduce pulmonary artery pressures. Randomised multi-centre studies in patients with acute lung injury have revealed no long-term benefit or outcome improvement.

0 0

Post a comment