HELLP syndrome

HELLP syndrome is a pregnancy related disorder associated with haemolysis, elevated liver function tests and low platelets. Criteria used for the diagnosis of HELLP are shown below.

• Microangiopathic haemolysis results from destruction of red cells as they pass through damaged small vessels.

• Hepatic dysfunction is characterised by periportal necrosis and hyaline deposits in the sinusoids. In some cases hepatic necrosis may proceed to hepatic haemorrhage or rupture.

Thrombocytopenia results from increased platelet consumption, although prothrombin time and activated partial thromboplastin time are normal, unlike in DIC.

0 0

Post a comment