Examples of drugs investigated in multicentre studies

• Corticosteroids (methylprednisolone, hydrocortisone)

• Polyclonal immunoglobulin

• Antitumour necrosis factor antibody

• Tumour necrosis factor soluble receptor antibody

• Interleukin-1 receptor antagonist

• Platelet activating factor antagonists, PAF-ase

• Bradykinin antagonists

• W-acetylcysteine, procysteine

• Antithrombin III

• Tissue factor pathway inhibitor

• Activated Protein C

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