Drug dosages


Alteplase (rt-PA)

The dose schedule for acute myocardial infarction is 10mgin 1-2min, 50mg in 1h and 40mg over 2h intravenously.


Single intravenous injection of 30U over 4-5min.


In acute myocardial infarction (1.5mu over 60min).In severe venous thrombosis (250,000U over 30min followed by 100,000U/h for 24-72h).


For unblocking indwelling vascular catheters 5000-37,500IU are instilled.

For thromboembolic disease 4400IU/kg is given over 10min followed by 4400IU/kg/h for 12-24h.

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