Drug dosages

Nitrates

Glyceryl trinitrate 2-40mg/h Isosorbide dinitrate 2-40mg/h

Sodium nitroprusside

20-400|jg/min.

ACE inhibitors

Captopril: 6.25mg test dose increasing to 25mg tds Enalapril: 2.5mg test dose increasing to 40mg o.d Lisinopril: 2.5 mg test dose increasing to 40mg o.d

Nifedipine:

5-20mg PO. Capsule fluid can be injected down nasogastric tube or given sublingually.

Phentolamine

2-5mg IV slow bolus. Repeat as necessary

Esmolol

A titrated loading dose regimen is commenced followed by an infusion rate of 50-200jg/kg/min.

Propranolol

Initially given as slow IV 1mg boluses repeated at 2min intervals until effect is seen (to maximum 5mg)

Labetalol

0.25-2mg/min

Hydralazine

5-10mg by slow IV bolus, repeat after 20-30min. Alternatively, by infusion starting at 200-300jg/min and reducing to 50-150jg/min.

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