Drug dosage

First line

Quinine

20mg quinine salt/kg IV over 4h, then 10mg/kg infusion over 4h, repeated 8-hrly until the patient can swallow, then tablets (10mg quinine salt/kg 8-hrly) to complete 7 days' treatment. Halve maintenance dose to 5mg salt/kg 8-hrly if continuing parenteral therapy for >48h.

Artemether

3.2mg/kg IM followed by 1.6mg/kg daily

Second line after asexual parasites eliminated

Sulfadoxlne

500mg/pyramethamine 25mg

3 tablets once

Doxycycllne

200mg then 100mg dally for 7 days

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