Drug dosage

Diamorphine

2.5mg IV. Repeat prn + anti-emetic

Streptokinase

1.5 million units in 100ml 0.9% saline IV over 1h

rt-PA

(alteplase)

100mg IV over 90min (15mg bolus, then 50mg over 30min, then 35mg over 60min

Reteplase

10units IV + further 10units IV 30min later

Aspirin

150mg PO od

Clopidogrel

75mg

Atenolol

50mg PO od (increase to 100mg od if not hypotensive and heart rate exceeds 70bpm) or 5mg slow IV bolus

Propranolol

10-40mg PO qds (titrate to heart rate of 60bpm)

Isosorbide dinitrate

2-40mg/h IV

GTN

10-200|jg/min IV or 0.5-1mg SL

Diltiazem

60mg PO tds

Nifedipine

5-10mg sublingual or PO tds

Atropine

0.3mg IV. Repeat to maximum of 2mg

Lidocaine

1mg/kg slow IV bolus then 2-4mg/min

Amiodarone

5mg/kg over 20min then infused up to 15mg/kg/day in 5% glucose via central vein (in emergency give 150-300mg in 10-20ml 5% glucose over 3min)

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