Diagnosis

• Unconjugated hyperbilirubinaemia, increased urinary urobilinogen (increased RBC breakdown)

• Reticulocytosis (increased RBC production)

• Splenic hypertrophy (extravascular haemolysis)

• Methaemoglobinaemia, haemoglobinuria, free plasma haemoglobin (intravascular haemolysis), reduced serum haptoglobins

• RBC fragmentation (microangiopathic haemolytic anaemia)

• Coombs' test (immune-mediated haemolysis)

• Other (including haemoglobin electrophoresis, bone marrow biopsy)

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