Definitions

Systemic inflammatory response syndrome (SIRS)

Two or more of:

• Respiratory rate > 20 breaths/min or PaCO2 <32mmHg (4.3kPa)

• WBC >12,000 cells/mm3, <4000/mm3, or >10% immature forms

Sepsis

The systemic response to infection. Definition as for SIRS but as a result of infection.

Severe sepsis

Sepsis associated with organ dysfunction, hypoperfusion or hypotension. These may include, but are not limited to, lactic acidosis, oliguria or an acute alteration in mental status.

Septic shock

Sepsis with hypotension, despite adequate fluid resuscitation, plus presence of perfusion abnormalities.

Multi-organ dysfunction syndrome (MODS)

Presence of altered organ function in an acutely ill patient such that homeostasis cannot be maintained without intervention. Multiple organ failure (MOF) has not achieved worldwide uniformity of definition.

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