Complications

• Circulatory instability

Intravascular volume changes Removal of circulating catecholamines Hypocalcaemia

• Reduced intravascular COP

If replacement with crystalloid

Reduced plasma opsonisation

Removal of coagulation factors

P.69

Indications Autoimmune disease

Goodpasture's syndrome Guillain-Barré syndrome Myasthenia gravis Pemphigus

Rapidly progressive glomerulonephritis SLE

Thrombotic thrombocytopenic purpura

Immunoproliferative disease

Cryoglobulinaemia Multiple myeloma

Waldenstrom's macroglobulinaemia

Poisoning

Paraquat

Others

Meningococcal septicaemia (possible benefit) Sepsis (possible benefit) Reye's syndrome

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