Common ICU causes

• Decreased platelet production, e.g. sepsis- or drug-induced

• Decreased production of coagulation factors, e.g. liver failure

• Increased consumption, e.g. DIC, major trauma, bleeding, heparin-induced thrombocytopenia, antiplatelet antibodies, extracorporeal circuits

• Impaired or deranged platelet function

• Decreased protease inhibitors, e.g. antithrombin III, Protein S and Protein C deficiency (following sepsis)

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